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Nutrigenetics and nontransmissible chronic diseases (NTCDs), such as cardiovascular diseases, cancer, diabetes mellitus type 2 and neurodegenerative diseases, are the main causes of morbidity and mortality worldwide. These pathologies develop as a consequence of a complex correlation between environmental and genetic factors and lifestyle, in which dietary patterns play a key role.
This line of investigation addresses such diseases from a nutrigenetic approach, a discipline that studies how individual genetic variants influence on the response of the organism to different dietary components. Nutrigenetics contributes to the development of the precision nutrition, an approach that allows taking advantage of human individuality to optimize prevention strategies and disease treatments.
The contribution of the interactions between the genetic variability and the diet to the development of NTCD is dependent on each population. This is due to, on the one hand, the fact that the frequency of risk genetic variants depends on the ancestry and, on the other hand, each population has its dominant dietary patterns. In Argentina, the latest data available demonstrate that there is a high prevalence of overweight, obesity, and NTCD linked to an inadequate diet. Also, current dietary patterns are characterized by a high intake of ultra-processed food rich in sugar, saturated fat and sodium and a low consumption of fruits and vegetables, what is translated into a low intake of dietary fiber and other phytonutrients. Therefore, the objective of our line of investigation is to generate knowledge applicable to the design of health policies, programs of prevention and strategies of personalized nutritional intervention.
To address the study of the genetic variability of our population, we participate in the Buenos Aires node of the Argentinean Population's Reference and Genomics Biobank Program (PoblAr).
Associations Between rs9939609 FTO Polymorphism With Nutrient and Food Intake and Adherence to Dietary Patterns in an Urban Argentinian Population.
Olmedo, Luciana ; Luna, Fernando ; Zubrzychi, Jeremías ; Dopazo, Hernán; Pellon-Maison M.
2024. Elsevier - Journal of the Academy of Nutrition and Dietetics - ISSN 2212-2672
doi: 10.1016/j.jand.2024.01.001
Validación de un cuestionario de frecuencia alimentaria para la estimación de la ingesta de azúcares libres y aliemntos ultraprocesados en población argentina.
Olmedo, Luciana ; Henning, María Florencia ; García, Silvia ; Pellon-Maison, Magali
2022. Revista Española de Ntrición Humana y Dietética - ISSN 2173-1292 - Elsevier Doyma
doi: 10.14306/renhyd.26.2.1565
Validación de un método enzimático-colorimétrico para la determinación de fructosa en refrescos comerciales.
Olmedo, Luciana ; Henning, Maria Florencia ; Pappalardo, Brenda ; García, Silvia ; Pellon Maison, Magali
2021. Revista Española de Nutrición Humana y Dietética, vol. 25 (pp. 69-77) - ISSN 2173-1292 - Elsevier Doyma
doi: 10.14306/renhyd.25.1.1087
Problematización acerca de la articulación entre extensión, docencia e investigación en la UNLP y su repercusión en la formación universitaria.
Fusé, Santiago Héctor ; Henning, Maria Florencia ; Karpenko Wilman, Ingrid Denise ; Pellon Maison, Magali
2020. Trayectorias Universtarias, vol. 6 (pp. 1-13) - ISSN 2469-0090 - Universidad Nacional de La Plata
doi: 10.24215/24690090e036
Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases -3 and -4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition.
Quiroga IY ; Pellon Maison, Magali ; Gonzalez, M ; Coleman, RA ; Gonzalez-Baro, MR
2020. ELSEVIER IRELAND LTD
Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages.
Quiroga, Ivana Yoseli ; Pellon Maison, Magali ; Suchanek, Amanda L. ; Grandinetti, Rosalinda ; Gonzalez Baro, Maria del Rosario
2019. BIOCHEMICAL JOURNAL, vol. 476 (pp. 85-99) PORTLAND PRESS LTD
doi: 10.1042/BCJ20180381
Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells.
Lacunza, Ezequiel ; Montanaro, Mauro Aldo ; Salvati, Annamaria ; Memoli, Domenico ; Rizzo, Francesca ; Henning, Maria Florencia ; Quiroga, Ivana Yoseli ; Guillou, Hervé ; Abba, Martin Carlos ; Gonzalez Baro, Maria Del Rosario ; Weisz, A ; Pellon Maison, Magali
2018. Oncotarget, vol. 9 (pp. 28141-28154) - ISSN 1949-2553 - Impact Journals
doi: 10.18632/oncotarget.25582
Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis.
Garcia-Fabiani, Maria Belen ; Montanaro, Mauro A ; Stringa, Pablo ; Lacunza, Ezequiel ; Cattaneo, Elizabeth R ; Santana, Marianela ; Pellon-Maison, Magali ; Gonzalez-Baro, Maria R
2017. BIOCHEMICAL JOURNAL PORTLAND PRESS LTD
doi: 10.1042/BCJ20161018
Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis.
Garcia Fabiani, Maria Belen ; Montanaro, Mauro Aldo ; Lacunza, Ezequiel ; Cattaneo, Elizabeth Renee ; Coleman, Rosalind A. ; Pellon Maison, Magali ; Gonzalez-Baró; MR
2015. BIOCHEMICAL JOURNAL, vol. 471 (pp. 211-220) Portland Press
doi: 10.1042/BJ20150730
Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
Pellon Maison, Magali ; Montanaro, Mauro Aldo ; Lacunza, Ezequiel ; Garcia Fabiani, Maria Belen ; Soler Gerino, Mercedes C ; Cattaneo, Elizabeth Renee ; Quiroga, Ivana Yoseli ; Abba, Martin Carlos ; Coleman, Rosalind ; Gonzalez Baro, Maria del Rosario
2014. PLOS ONE, vol. 9 (pp. 1-8) Public Library of Science
doi: 10.1371/journal.pone.0100896
Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response.
Lacunza, Ezequiel ; Rabassa, Martín Enrique ; Canzoneri, Romina ; Pellon Maison, Magali ; Croce, María Virginia ; Aldaz, Claudio Marcelo ; Abba, Martin Carlos
2014. CELL STRESS & CHAPERONES., vol. 19 (pp. 379-388) Springer
doi: 10.1007/s12192-013-0466-3
Apolipoprotein A-I Helsinki promotes intracellular acyl-CoA cholesterol acyltransferase (ACAT) protein accumulation.
Toledo, Juan Domingo ; Garda, Horacio Alberto ; Cabaleiro, Laura Virginia ; Cuellar, Angela ; Pellon Maison, Magali ; Gonzalez Baro, Maria del Rosario ; Gonzalez, Marina Cecilia
2013. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 377 (pp. 197-205) Springer
doi: 10.1007/s11010-013-1585-y
Rol de la isoforma 2 de la glicerol-3-fosfato aciltransfersa 2 en el metabolismo lipídico testicular.
Cattaneo, ER ; Pellon Maison, Magali ; Gonzalez-Baro, MR
2013. Acta Bioquímica Clínica Latinoamericana, vol. 47 (pp. 315-325) Federacion Bioquímica Provincia Buenos Aires
S0325-29572013000200009
Glycerol-3-Phosphate Acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols.
Cattaneo, ER ; Pellon Maison, Magali ; Rabassa, ME ; Lacunza, E ; Coleman, RA ; Gonzalez-Baro, MR
2012. PUBLIC LIBRARY SCIENCE. PLOS ONE, vol. 7 (pp. 1-11)
doi: 10.1371/journal.pone.0042986
Photosensitization of DNA by β-carbolines: Kinetic analysis and photoproduct characterization.
Gonzalez, Micaela M ; Vignoni, M ; PELLON MAISON, MAGALI ; Ales-Gandolfo, MA ; Gonzalez-Baro, MR ; Erra-Balsells, R ; Epe, B ; Cabrerizo, FM
2012. ROYAL SOC CHEMISTRY. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10 (pp. 1807-1819)
doi: 10.1039/C2OB06505C
Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids.
Hein, GJ ; Bernasconi, AM ; Montanaro, MA ; Pellon-Maison M ; Finarelli, GS ; Chicco, A ; Lombardo, YB ; Brenner, RR
2010. AMER PHYSIOLOGICAL SOC. Organic & Biomolecular Chemistry, vol. 8 (pp. 2543-2552)
doi: 10.1152/ajpendo.00513.2009
Photosensitized cleavage of plasmidic DNA by.
Pellon-Maison M, ; García, CF ; Cattaneo, ER ; Coleman, RA ; Gonzalez-Baro, MR
2010. Royal Society of Chemistry. Organic & Biomolecular Chemistry, vol. 8 (pp. 2543-2552)
doi: 10.1039/C002235G
Macrobrachium borellii hepatopancreas contains a mitochondrial glycerol-3-phosphate acyltranferase which initiates triacylglycerol biosynthesis.
Pellon-Maison M, ; García, CF ; Cattaneo, ER ; Coleman, RA ; Gonzalez-Baro, MR
2009. AOCS Press. LIPIDS, vol. 44 (pp. 337-344)
doi: 10.1007/s11745-008-3275-1
Effect of fish oil on the unsaturated fatty acid metabolism in dyslipidemic sucrose fed rats.
Brenner, RR ; Bernasconi, AM ; Montanaro, MA ; Pellon-Maison, Magali ; Finarelli, GS ; Hein, GJ ; Chicco, A ; Lombardo, YB
2008. ElSevier. Chemistry and Physics of Lipids, vol. 154 (pp. 44-44) ELSEVIER IRELAND LTD
doi: 10.1016/j.chemphyslip.2008.05.118
Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV).
Magalí Pellon-Maison, Mauro A Montanaro, Rosalind A Coleman, María R Gonzalez-Baró
2007. ElSevier. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
doi: 10.1016/j.bbalip.2007.04.001
The C-terminal region of mitochondrial glycerol-3-phosphate acyltransferase-1 interacts with the active site region and is required for activity.
Magalí Pellon-Maison, Rosalind A Coleman, María R. Gonzalez-Baró.
2006 - Archives of Biochemistry and Biophysics, vol. 450 (pp. 157-166).
doi: 10.1016/j.abb.2006.03.009
