Study of lipid-lipid and lipid-protein interaction related to the organization and structure of biological membranes


Team of work

Maté, Sabina María
Principal Investigator
mate.sabina@gmail.com
Herlax, Vanesa
Investigator
herlax@hotmail.com
Godoy, Joshua
Thesis Students
Bernasconi, Ana
Support staff
ambernas@hotmail.com
Hernández, Laura Edith
Support staff
lauraeh1900@hotmail.com
   


Collaborators from other institutions

International


Goñi, Félix M.
Unidad de Biofísica-Centro Mixto, Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, España.

Busto, Jon V.
Unidad de Biofísica-Centro Mixto, Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, España.

Sot, Jesús
Unidad de Biofísica-Centro Mixto, Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, España.


National


Bakas, Laura

Centro de Investigación de Proteínas Vegetales (CIPROVE), Facultad de Ciencias Exactas, UNLP. La Plata. prov. de Buenos Aires. Argentina

Vázquez, Romina
Facultad de Cs. Exactas, UNLP e INIBIOLP, CCT-La Plata.

Daza-Millone, Antonieta
Facultad de Cs. Exactas, UNLP e INIFTA, CCT-La Plata.

Farina, Mariana
Laboratorio de Fisiopatología Placentaria, CEFyBO-CONICET, Argentina.

Damiano, Alicia
Laboratorio de Biología de la Reproducción, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, IFIBIO-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Argentina .

Line overview

The main objective of the present line of work consists in the study of lipid-lipid and lipid-protein interactions for the organization and structure of biological membranes. For the development of the present line biochemical and traditional biophysical methodologies are utilized as well as the more recent development methodologies, such as AFM and force spectroscopy, resonance of surface Plasmon, scale of Langmuir, Brewster Angle Microscopy, among others.

Publications

 

  • Relationship between intracellular calcium and morphologic changes in rabbit erythrocytes: Effects of the acylated and unacylated forms of E. coli alpha-hemolysin.
    Vazquez, R; Mate, S; Bakas, L; Garcia Muñoz, C; Herlax, V.
    2016. Biochimica et biophysica acta-biomembranes, Amsterdam: ELSEVIER SCIENCE BV, vol. 1858, n° 8, p. 1944-1953. ISSN 0005-2736
  • The unfavorable lipid environment reduced caveolin-1 expression in apical membranes from humanpreeclamptic placentas.
    Levi, L; Castro Parodi, M; Martínez, N; Piehl, L; Rubín De Celis, E; Herlax, V; Mate, S; Farina, M; Damiano, A. E.
    2016. Biochimica et Biophysica Acta-Biomembranes. Amsterdam: ELSEVIER SCIENCE BV, vol. 1858, n° 9, p. 2171-2180. ISSN 0005-2736
  • Induction of eryptosis by low concentrations of E. coli alpha-hemolysin.
    Carrizo, F; Maté, S; Bakás, L; Herlax, V.
    2015.
    Biochimica et Biophysica Acta-Biomembranes. , Amsterdam: ELSEVIER SCIENCE BV, vol. 1848, p. 2779
    -2788. ISSN 0005-2736
  • Boundary region between coexisting lipid phases as initial binding sites for Escherichia coli alpha-hemolysin: a real-time study.
    Maté, S; Vázquez, R; Herlax, V; Daza-Millone, M, A; Fanani, M. L; Maggio, B; Vela, M. E; Bakás, L. 
    2014. Biochimica et Biophysica acta-Biomembranes. : ELSEVIER SCIENCE BV,. vol. 1838, p. 1832-1841. ISSN 0005-2736


  • N-nervonoylsphingomyelin (c24:1) prevents lateral heterogeneity in cholesterol-containing membranes.
    Maté, S; Busto, J; García-Arribas, A; Sot, J; Vázquez, R; Herlax, V; Wolf, C; Bakás, L; Goñi, F. M. 
    2014. Biophysical Journal. , United States: CELL PRESS,. vol. 106, p. 2606-2616. ISSN 0006-3495


  • Novel evidence for the specific interaction between cholesterol and alpha- haemolysin of Escherichia coli.
    Vázquez, R. F; Maté, S. M; Bakás, L, S; Fernández, M. M; Malchiodi, E. L; Herlax, V. S. 
    2014. Biochemical Journal. , Londres: PORTLAND PRESS LTD,. vol. 458, n° 3, p. 481-489. ISSN 0264-6021

  • Mecanismo de acción de la toxina alfa hemolisina de Escherichia Coli. 
    Bakás, L; Maté, S; Vázquez, R; Herlax, V. 
    2013
    . Acta bioquímica clínica latinoamericana. La Plata: Federación BioquímicaProvincia Buenos Aires. Vol. 47, n° 2, p. 353-361. ISSN 0325-2957


  • E.coli Alpha Hemolysin and properties 
    Bakás, L; Maté, S; Vazquez, R; Herlax, V.
    2012. Biochemistry, BooK I, Ed. Prof. Deniz Ekinci, Croacia. 

    http://www.intechopen.com/articles/show/title/e-coli-alpha-hemolysin-and-properties

  • Relevance of fatty acid covalently bound to Escherichia coli alpha-Hemolysin and membrane microdomains in the oligomerization process. 
    Herlax, V; Maté, S; Rimoldi, O; Bakas, L. 
    2009. Journal of Biological Chemistry. Amer Soc Biochemistry Molecular Biology, Inc, vol. 284, p. 25199-25210


Book - Book chapters

  • Alfa- Hemolisina de Escherichia coli: Prototipo de las toxinas RTX (Repeat in Toxin). Un estudio de las etapas de su mecanismo de acción.
    Vázquez, R; Maté, S; Herlax, V; Bakás, L; Álvarez Valcárcel, C; Pazos Santos, F.
    2016. Puebla: Benemérita Universidad Autónoma De Puebla, p. 191-213. ISBN 978-607-525-046-5


  • Role of sphingomyelin in membrane-domain formation and the influence on protein interaction: focusing on the nanometer scale.
    Maté, S; Herlax, V; Vázquez, R; Bakás, L.
    2016. Nueva York: NovaScience Publishers, p. 89-112. ISBN 978-1-63484-581-6


  • E. coli Alpha Hemolysin and Properties. 
    Bakás, L; Maté, S; Vázquez, R; Herlax, V.
    2012. InTech, p. 107-140. ISBN 978-953-51-0076-8




INIBIOLP - Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner"
Consejo Nacional de Investigaciones Científicas y Técnicas - Facultad de Ciencias Médicas - U.N.L.P.
Avenida 60 y 120 - C.P. 1900 La Plata - Prov. de Buenos Aires - Argentina. Tel. 54-221-4824894 - Fax. 54-221-4258988 - E-mail :