Gene transfer assisted by magnetic nanoparticles
and external magnetic fields.
Nanomedicine applications in cell reprogramming,
gene therapy, and cell therapy

Team of work

Goya, Rodolfo Gustavo
Principal Investigator
Pereyra, Andrea Soledad
Research Fellow

Sosa, Yolanda Elena
Support Staff
Scelsio, Natalia
Support Staff

Collaborators from other institutions


Delbono, Osvaldo
Biología del musculo esquelético, Wake Forest University School of Medicine, NC, USA.

Mykhaylyk, Olga
Formulación de nano partículas magnéticas y aplicaciones biomédicas, Department of Experimental Oncology and Therapy Research, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.


Álvarez, Vera
Instituto de Investigaciones en Ciencia y Tecnología de materiales (hidrogeles y fantomas de matriz polimérica y polímeros nanoestructurados, INTEMA, UNMDP-CONICET).

Arciniegas, Lorena
Instituto de Investigaciones en Ciencia y Tecnología de materiales (hidrogeles y fantomas de matriz polimérica y polímeros nanoestructurados, INTEMA, UNMDP-CONICET).

Bruvera, Ignacio
Instituto de Física La Plata (IFLP, UNLP-CONICET) / Magnetismo y materiales magnéticos.

Fernández van Raap, Marcela
Instituto de Física La Plata (IFLP, UNLP-CONICET) / Magnetismo y materiales magnéticos.

González, Jimena
Instituto de Investigaciones en Ciencia y Tecnología de materiales (hidrogeles y fantomas de matriz polimérica y polímeros nanoestructurados, INTEMA, UNMDP-CONICET).

Hoppe, Cristina
Instituto de Investigaciones en Ciencia y Tecnología de materiales (hidrogeles y fantomas de matriz polimérica y polímeros nanoestructurados, INTEMA, UNMDP-CONICET).

Mendoza Zélis, Pedro
Instituto de Física La Plata (IFLP, UNLP-CONICET) / Magnetismo y materiales magnéticos.

Pasquevich, Gustavo
Instituto de Física La Plata (IFLP, UNLP-CONICET) / Magnetismo y materiales magnéticos.

Sánchez, Francisco
Instituto de Física La Plata (IFLP, UNLP-CONICET) / Magnetismo y materiales magnéticos.

Tricerri, Maria Alejandra
Instituto de Investigaciones Bioquímicas de La Plata “Doctor Rodolfo R. Brenner” INIBIOLP (evaluación de la interacción nanoparticulas magnéticas-adenovirus mediante técnica de FRET).

Line overview

One of the nanotechnological areas of greatest evolution is based on the use of nanoparticles with magnetic properties (MNPs) to improve the transfer of diverse diagnostic, therapeutic, synthetic or biological molecules to cells and tissues, process named magnetofection. Given their reduced size, the Magnetic Nanoparticles (MNPs) used in biomedicine have the peculiarity of being compatible for their association with cells, virus, proteins, and nucleic acids, and of migrating to the sites of interest with the least alteration of cellular functions. The introduction of nucleic acids (DNA or NRA) into eukaryotic cells is called transfection, and according to the nature of the vector that transports such molecule it is classified in viral (transductions) and non-viral transfectiones. The most used viral systems are undoubtedly Recombinant Adenovirus (rAds) because of, among other advantages, their non-integrated nature to genome of host cell, their low pathogenicity, and the capacity of being produced relatively simple and on a large scale. We glimpse that our project of investigation will be useful to optimize cell and gene transfer to animal tissues, without exhausting its applicability in the herein proposed biological models.

Magnetofection applied to in vivo cell and gene therapy

We have recently demonstrated how the combination of adenoviral vectors with MNPs in the presence of a magnetic field reaches high transduction efficiency with minimum toxicity in diverse cellular lines such as B92, HEK293, CHO and especially mature C2C12 myotubes which are naturally refractory to these adenoviruses. However, the translation of this technology to in vivo models represents a true challenge. The success of magnetofection in this context substantially resides in finding those conditions in which the mechanic-biological properties of the tissue, the quantity of administered MNPs, and the magnitude of the applied magnetic field are combined in such a way as to maximize the transit time of magnetovectors by the regions where gene or cell transfer (magnetophoresis) is intended to be emphasized. To do so, we have an artificial model (phantom) of skeletal muscle based on polyvinylalcohol (PVA) hydrogels that remedy the mechanical-elastic characteristics of the murine skeletal muscle. On them it will be studied the conditions that influence magnetoforesis of viral magneto-vectors and magnetized cells; in a second stage we will validate our findings in male C57BL/6 mice in order to evaluate the efficiency of in vivo magnetoefection from a biological perspective.

Magnetofection applied to cell reprogramming

The discovery of pluripotency genes (Yamanaka’s genes) whose over-expression allows that adult somatic cells can be completely reprogrammed into induced pluripotency stem cells (iPSCs) has greatly inspired the development of replacement therapies to diverse conditions characterized by acute loss, degeneration, or severe functional alteration of cellular populations residing in the tissues. In our laboratory it is of great interest the manipulation of myoblasts and fibroblasts for their direct reprogramming to other cell lines such as cardiomyocytes or neurons and their subsequent transplantation to injured organs. A critical aspect for clinical future applicability of this technique is the development of gene transfer methods that become efficient and safe for cell reprogramming and for their future receptors. In this line of work we propose by means of the use of MNPs and external magnetic fields to assist the transfer of adjustable plasmid vector that is being built in out laboratory, that codes for human genes sox2, c-myc, klf4, and oct4 to adult somatic cells such as fibroblasts and myoblasts, and to analyze the efficiency, toxicity, the effect on future cell phenotypes, so on. We also investigate other benefits of using MNPs such as cell marking and their subsequent manipulation through magnetic fields in order to improve implantation in the corresponding seat and allow its visualization by non-invasive methods such as Nuclear Magnetic Resonance.




  • Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats.
    Pardo, J; Abba, M. C; Lacunza, E; Francelle, L; Morel, G. R; Outeiro, T. F; Goya, R. G.
    . Hippocampus. Apr;27(4):435-449. Doi: 10.1002/hipo.22703
    Epub 2017 Jan 23. PubMed PMID: 28085212

  • Racemized and isomerized proteins in aging rat teeth and eyelens. Rejuvenation research.
    Warmack, R; Mansilla, E; Goya, R. G; Clarke, S. G.
    2016. New York: MARY ANN LIEBERT INC, vol. 19, n° 4, p. 309-317. ISSN 1549-168

  • Therapeutic potential ofigf-i on hippocampal neurogenesis and function during aging.
    Morel, G. R; Lopez-León, M; Uriarte Donati, M; Reggiani, P. C; Goya, R. G.
    2016. Neurogenesis, Austin (Texas): London: Taylor & Francis Group, LLC, vol. 4, n° 1, ISSN 2326-2133
  • Stress-induced Gene Expression Sensing Intracellular HeatingTriggered by Magnetic Hyperthermia.
    De Sousa, M. E; Carrea, A; Mendoza Zélis, P; Muraca, D; Mykhaylyk, O; Sosa, Y. E; Goya, R. G; Sánchez, F. A; Dewey, R; Fernández Van Raap, M. B.
    2016. Journal of Physical Chemistry c. Washington: Amer Chemical Soc, vol. 120, p. 7339-7348. ISSN 1932-7447

  • Magnetofection EnhancesAdenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.
    Pereyra, A. S; Mykhaylyk, O; Falomir Lockhart, E; Taylor, J. R; Delbono, O; Goya, R. G; Plank, C; Hereñu, C. B.
    2016. J Nanomed Nanotechnology: OMICS International, vol. 7, n° 2, ISSN 2157-7439

  • A rat treated with mesenchymal stem cells livesto 44 months of age.
    Mansilla. E; Roque. G; Sosa. Y. E; Tarditti, A; Goya, R. G.
    2016. Rejuvenation Research. New York: MARY ANN LIEBERT INC, vol. 19, n° 4, p. 318-321. ISSN 1549-1684
  • Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats.
    Pardo, J; Uriarte, M; Cónsole, G. M; Reggiani, P; Outeiro, T. F; Morel, G. R; Goya, R. G.
    . Eur J Neurosci. Aug;44(4):2120-8. Doi: 10.1111/ejn.13278
    Epub 2016 Jun 8. PubMed PMID: 27188415

  • Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1 and enhances skeletal muscle force in aging sedentary mice.
    Zhang, T; Pereyra, A. S; Wang, Z. M; Birbrair, A; Reisz, J. A; Files, C. D; Purcell, L; Feng, X; Messi, M. L; Feng, H; Chalovich, J; Jin, J-P; Furdui, C; Delbono, O.
    2016. Aging Cell. 2016 Feb 19. doi: 10.1111/acel.12453

  • Troponin T3 regulates nuclear localization of the calcium channel CavB1a subunit in skeletal muscle.
    Zhang, T; Taylor, J; Jiang, Y; Pereyra, A. S; Messi, M; Wang, Z. M; Hereñú, C; Delbono, O.
    2015. Experimental Cell Research. 2015 May 15; 336 (2): 276-286

  • Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.
    D. Clark Files; Liu, C; Pereyra, A. S; Zhong-Min Wang; Aggarwal, N; D´Alessio, F; Delbono, O.
    2015. Science Translational Medicine. , Washington: American Association for the Advancement of Science, vol. 7, n° 278, p. 278-310. ISSN 1946-6234

  • Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats.
    Morel, G; Andersen, T; Pardo, J; Zucolilli, G. O; Cambiaggi, V. L; Hereñú, C; Goya, R. G.
    Neuroscience. , Amsterdam: PERGAMON-ELSEVIER SCIENCE LTD, p. 189-199. ISSN 0306-4522

  • Regional research priorities in brain and nervous system disorders
    Ravindranath, V; Dang, H. M; Goya, R. G; Mansour, H; Nimgaonkar, V. L; Russell, V. A; Xin, Y.
    2015. Nature, 527: S198–S206

  • Estrogen actions on glial reactivity and inflammation-mediated memory impairment: Sex differences and interaction with other neurotrophic factors.
    Bellini, M. J.
    2015. González-Burgos (Ed.); Nova Science Publishers, July 01, 2015, Pages 155-174

  • Neuroprotective gene therapy in the aging brain.
    Pardo, J; Morel, G. R; Pereyra, A. S; López-León, M; Brown-O. A, Bellini, M. J; Goya, R. G.
    2014. Estrogens and Cognition. Psycho-biological and Clinical Aspects: González-Burgos (Ed.) ISBN: 978-81-308-0550-4; pp.97-117

  • Therapeutic potential of the thymic peptide thymulin
    Reggiani, P. C; Schwerdt, J. I; Cónsole, G. M; Roggero, E; Dardenne, M; Goya, R. G.
    2014. Current Pharmaceutical Design, 20: 4690-4696

  • Physiology and therapeutic potential of the thymic peptide thymulin.
    Reggiani, P. C; Schwerdt, J. I; Console, G. M; Roggero, E. A; Dardenne, M; Goya, R. G. 
    2014. Current Pharmaceutical Design. , Oak Park: BENTHAM SCIENCE PUBL LTD,. vol. 20, n° 29, p. 4690-4696. ISSN 1381-6128
  • Regenerative Medicine for the Aging Brain.
    Lopez Leon, M; Reggiani, P; Hereñú, C; Goya, R.
    2014. Herbert Publication,. vol. 1, n° 1, p. 1-9. ISSN 2050-1218.
    Enliven J Stem Cell Res Regen Med.
  • The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells.
    Taylor, J; Pereyra, A. S; Zhang, T; Messi, M. L; Zhong-Min Wang; Hereñú, C; Pei-Fen Kuan; Delbono, O. 
    2014. Journal of Cell Biology. , New York: ROCKEFELLER UNIV PRESS,.vol. 205, n° 6, p. 829-846. ISSN 0021-9525
  • DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma.
    Da Silva, A.L; Martini, S. V; Abreu, S.C; Samary, C. D; Diaz, B. L; Fernezlian S de Sá, V. K; Capelozzi, V. L; Boylan, N. J; Goya, R. G; Suk, J. S; Rocco, P. R; Hanes, J; Morales, M. M.
    2014. Journal of Controlled Release. Amsterdam: ELSEVIER SCIENCE BV. vol. 180, p. 125-133. ISSN 0168-3659
  • Gene therapy and cell reprogramming for the aging brain: achievements and promise.
    Pardo, J; Morel, G. R; Astiz, M; Schwerdt, M. I; López León, M; Rodríguez, S. S;Hereñú, C. B; Goya, R. G. 
    2014. Curr Gene Ther; 14:24-34
  • Transferencia génica asistida por campos magnéticos: estudios en células gliales.
    Pardo, J; Sosa, Y; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G. 
    2013. Acta Bioquímica Clínica Latinoamericana. La Plata: Federacion Bioquímica Provincia Buenos Aires, vol. 47, n° 2, p. 399-406. ISSN 0325-2957
  • The thymulin-lactotropic axis in rodents: thymectomy, immunoneutralization and gene transfer studies.
    Martines, E. V; Reggiani, P. C; Camihort, G; Luna, G; Zappa, M. F; Brown, O. A; Goya, R. G; Cónsole, G. M. 
    2013Neuroimmunomodulation. Basel: Karger. vol. 20, p. 256-263. ISSN 1021-7401
  • Hypothalamic insulin-like growth factor-I gene therapy prolongs estral cyclicity and protects ovarian structure in middle-aged female rats.
    Rodriguez, S. S; Schwerdt, J. I; Barbeito, C. G; Flamini, A. M; Han, Y; Bohn, M. C; Goya, R. G.
    2013. Endocrinology.Bethesda: Endocrine Soc. vol. 154, n° 6, p. 2166-2173. ISSN 0013-7227
  • Magnetic field-assisted gene transfer: Studies in glial cells (in Spanish).
    Pardo, J; Sosa, Y. E; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G. 
    2013. Acta Bioquímica Latinoamericana; 47: 399-406
  • Role of copper and cholesterol association in the neurodegenerative process.
    Arnal, N; Morel, G. R; Tacconi de Alaniz, M. J; Dominici, L; Marra, C. A.  
    2013. Int J Alzheimers Dis; 2013:414817. doi: 10.1155/2013/414817. Epub 2013 Oct 29
  • Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β. 
    Grassi, D; Bellini, M. J; Acaz-Fonseca, E; Panzica, G; Garcia-Segura, L. M. 
    2013. Endocrinology. 154: 2092-100
  • Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice. 
    Diz-Chaves, Y; Astiz, M; Bellini, M. J; Garcia-Segura, L. M. 
    2013Brain Behavior and Immunity. Amsterdam: Academic Press Inc Elsevier Science. vol. 28, p. 196-206. ISSN 0889-1591
  • Magnetic field-assisted gene delivery: achievements and therapeutic potential.
    Schwerdt, J. I; Goya, G. F; Calatayud, P; Hereñu, C; Reggiani, P. C; Goya, R. G. 
    2012. Current gene therapy. , Oak Park: Bentham Science Public  Ltd, vol. 12,n° 1, p. 116-126

  • Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuates reproductive derangements in nude female mice.
    Reggiani, P. C; Barbeito, C. G; Zuccolilli, G. O; Cónsole, G. M; Flamini, A. M; Dardenne, M; Goya, R. G. 
    2012. Endocrinology. : Endocrine Soc, vol. 153, n° 8, p. 3922-3928

  • Role of thymulin on the somatotropic axis in vivo. 
    Reggiani, P.C; Martinez,  E; Camihort, G.A; Poch, B; Goya, R. G; Console, G. M. 
    2012. Life Sciences, Amsterdam: Pergamon - ElSevier Science Ltd, vol. 91, p. 166-171

  • Influence on Effectiveness of Early Treatment with Anti-TNF Therapy in Rheumatoid Arthritis. 
    Escudero-Vilaplana, V; Ramírez-Herraiz, E; Trovato-López, N; Alañón-Plaza, E; Bellini, M; Herranzalonso, A; Bellón-Cano, J.M; Morell-Baladrón, A; Sanjurjo-Sáez, M. 
    2012. Journal of pharmacy and pharmaceutical sciences. : Canadian Soc Pharmaceutical Sciences, vol. 15, n° 3, p. 355-360

  • Selective oestrogen receptor modulators decrease the inflammatory response of glial cells. 
    Arevalo, M.A; Diz-Chaves, Y; Santos-Galindo, M; Bellini, M.J; Garcia-Segura, L.M. 
    2012. Journal of neuroendocrinology. Oxford: Wiley-Blackwell Publishing, Inc, vol. 24, p. 183-190
  • Increased romatase expression in the hippocampus of spontaneously hypertensive rats: effects of estradiol administration. 
    Pietranera, L; Bellini, M. J;  Arévalo, M. A; Goya, R; Brocca, M. E; García Segura, L. M; De Nicola, A. F.
    2011. Neuroscience, 174p. 151-159
  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.
    Reggiani, P. C; Poch, B; Cónsole, G. M; Rimoldi, O. J; Schwerdt, J. I; Tüngler, V; García-Bravo, M. M; Dardenne, M; Goya, R. G.
    2011.  J Ethnopharmacol 136, 204–209. Editorial: Elsevier.
  • Increased number of neurons in the cervical spinal cord of aged female rats.
    Portiansky, E. L; Nishida, F; Barbeito, C. G; Gimeno, E. J; Goya, R. G.
    2011. PloS One, 6: e22537
  • Insulin-like growth factor I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide.
    Bellini, M. J; Hereñú, C. B; Goya, R. G; García Segura, L. M.
    2011. Neuroinflammation,  8: 21
  • Restorative effect of intracerebroventricular Insulin-like Growth Factor-I gene therapy on motor performance in aging rats.
    Nishida, F; Morel, G. R; Hereñú, C. B; Schwerdt, J. I; Goya, R. G; Portiansky, E.L
    2011. Neuroscience, 177: 195 - 206
  • Thymulin-based gene therapy and pituitary function in animal models of aging.
    Reggiani, P. C; Poch, B; Cónsole, M. G; Rimoldi, O. J; Schwerdt, J. I; Tüngler, V; García de Bravo, M. M; Dardenne, M; Goya, R. G.
    2011. Neuroimmuno-modulation,  18: 350-356
  • Morphological effects on the corticotrope population by thymulin gene therapy in nude mice.
    Martinez, E. V; Reggiani, P. C; Schwerdt, J. I; Goya, R. G; Cónsole, G. M.             
    2011. Histology and Histopathology; 26: 471-479
  • Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.
    Martinez, E. V; Reggiani, P. C; Schwerdt, J. I; Goya, R. G; Cónsole, G. M.
    2011. Cells, Tissues, Organs, 194: 67-75
  • Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior; adult mice: a potential model of geriatric depression.
    Mitschelen, M; Yan, H; Farley, J. A; Warrington, J. P; Han, S; Hereñú, C. B; Csiszar, A; Ungvari, Z; Bailey-Downs, L. C; Bass, C. E; Sonntag, W. E. 
    2011. Neuroscience; 185: 50 - 60
  • Morphological changes induced by insulin-like growth factor-I gene therapy in pituitary cell populations in experimental prolactinomas. 
    Camihort, G. A; Hereñú, C. B; Luna, G. C; Rodríguez, S. S; Bracamonte, M. I; Goya, R. G; Cónsole, G. M.
    2010. Cells tissues organs. Karger. vol. 191, p. 316-325

  • Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats
    Morel, G. R; Sosa, Y. E; Bellini, M. J; Carri, N. G; Rodriguez, S, S; Bohn, M. C; Goya, R.
    . Neuroscience; vol. 167 p. 946 - 953
  • Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord. 
    Rodríguez de Amorim, M. A; García-Segura,  L. M; Goya, R, G; Portiansky, E. L.2010Experimental gerontology. Pergamon-Elsevier Science Ltd. vol. 45, p. 457-463
  • Carbohydrates and glycoforms of the major egg perivitellins from Pomacea apple snails (Architaenioglossa: Ampullariidae).
    Morel, G; Sosa, Y. E; Bellini, M. J; Carri, N. G; Rodriguez, S; Bohn, M. C; Goya, R. G. 
    2010. Neuroscience. Pergamon-Elsevier Science Ltd. vol. 167, p. 946-953
  • The ependymal route for insulin-like growth factor-1 gene therapy in the brain. 
    Hereñu C. B; Sonntag W.E; Morel G. R; Portiansky E. L; Goya R. G. 
    2009. Neuroscience. Elsevier, vol. 163, p. 442-447
  • Morphological Restoration of Gonadotrope Population by Thymulin Gene Therapy in Nude Mice. 
    Reggiani P; Martínez E; Ferese C; Goya R; Cónsole G. 
    202009. Histology and Histopathology. Murcia, Spain: Gutenberg, vol. 24,nº6, p.729-735
  • The thymus-neuroendocrine axis: physiology, molecular biology and therapeutic potential of the thymic peptide thymulin.
    Reggiani P.C; Morel G. R; Cónsole G. M; Barbeito C. G; Rodriguez S; Brown O. A; Bellini M. J; Pléau J. M; Dardenne M; Goya R. G. 
    2009. Annals of the New York Academy of Sciences. New York: New York Academy of Sciences. Blackwell Publishing, vol. 1153, p. 98-106
  • Effect of insulin-like growth factor- I gene therapy on the somatotropic axis in experimental prolactinomas. 
    Console G.M; Hereñú C. B; Camihort G. A; Luna G. C; Ferese C; Goya R.G. 
    2009. Cells Tissues Organs. Basel: Karger AG, vol. 190, p. 20-26
  • Estrogen inhibits tuberoinfundibular dopaminergic neurons but does not cause irreversible damage.
    Morel, G. R; Caron, R. W; Console, G. M; Soaje, M; Sosa, Y. E; Rodríguez, S. S; Jahn, G. A; Goya, R. G. 
    2009. Brain Research Bulletin. Amsterdam: Elsevier, vol. 80, n° 6, p. 347-352
  • Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas. 
    Console, G. M; Hereñu, C. B; Camihort, G. A; Luna, G. C; Bracamonte, M. I; Morel, G. R; Goya, R. G. 
    2008. Molecular cancer. Londres: Blackwell Scientific Publications, p. 7-13
  • Dopaminergic mesencephalic systems and motor performance in very old rats. 
    Sánchez, H. L; Silva, L. B; Portiansky, E. L; Hereñu, C. B; Goya, R. G. 
    2008. Neuroscience. USA: Elsevier, vol. 154, n° 4, p. 1598-1606
  • Preventive action of neonatal gene therapy with the thymic hormone thymulin on the ovarian atrophy of adult nude mice.
    Reggiani, P.C; Flamini, M. A; Rodriguez, S. S; Goya, R. G; Barbeito, C. G. 
    2008. Biocell. Mendoza: IHEM-CONICET, vol. 32, p. 137-137
  • Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models. 
    Morel, G. R; Reggiani, P. C; Cónsole, G. M; Rimoldi, O. J; Vesenbeckh, S. M; García De Bravo, M; Rodríguez, S. S; Brown, O. A; Goya, R. G. 
    2008.Curr gene ther. Bentham Science Publishers, vol. 8,n° 1,p.49-53.ISSN 1566-5232
  • Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models.
    Morel G. R; Reggiani P. C; Console, G. M; Rimoldi, O. J; Vesenbeckh, S. M; Garcia De Bravo M. M; Rodriguez, S. S; Brown, O. A; Goya, R. G. 
    2007. Curr gene ther... vol. 8, p. 49-53
  • PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes. 
    Cristina, C; Diaz Torga, G; Goya, R. G; Kakar, S. S; Perez Millan, M. I; Giannella Neto, D; Bronstein, M. D; Becu Villalobos, D. 
    2007. Molecular cancer. Inglaterra: BMC. vol. 6, p. 4-9
  • Fatty acid profiles in hepatic membranes of rats with different levels of circulating estrogen and prolactin. 
    Bellini, M. J; Carino, M; Tacconi de Gomez Dumm, I. N; Goya, R. G. 
    2007. Comparative biochemistry and physiology molecular and integrative physiology. USA: Elsevier. vol. 146, p. 470-474
  • Restorative effect of Insulin-like Growth Factor-I Gene Therapy in the Hypothalamus ofsenile rats with Dopaminergic dysfunction.
    Hereñu, C. B; Cristina, C; Rimoldi, O. J; Becu-Villalobos, S; Cambiaggi, V; Portiansky, E. L; Goya, R. G. 
    2007. Gene therapy. Nature Publishing Group. vol. 14, p. 237-245. ISSN 0969-7128
  • Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. 
    Goya, R. G; Reggiani, P. C; Vesenbeckh, S. M; Pleau, J. M; Sosa, Y. E; Console, G. M; Schade, R; Henklein, P; Dardenne, M. 
    2007. American journal of physiology-endocrinology and metabolism. American Physiological Society. vol. 293, p. 182-187

Book - Book chapters

  • Logros y promesas de la medicina regenerativa en el tratamiento de enfermedades neurodegenerativas.
    López-León, M; Lehmann, M; Goya, R. G.
    2016. Universidad de Murcia (Master); 6º Ed.; Viguera Editores SLU; Barcelona; 2016. Capítulo en el libro “Desordenes del Movimientro”.

  • Medicina regenerativa para el tratamiento de enfermedades nuerodegenerativas.
    López-León, M: Goya, R. G.
    2015. Universidad de Murcia (Master); 5º Ed.; Viguera Editores SLU; Barcelona. Capítulo en el libro “Desordenes del Movimientro”

  • Gene Delivery Systems. 
    Pereyra, A. S; Hereñu, C. B.; Romanovsky, V; Zgela, V; Bakic, S.
    2013. Editorial InTech, p. 165-192. ISBN 978-953-51-1207-5
  • Neuroendocrine system and aging: growth hormone, thyroid stimulating hormone, prolactin and insulin.
    Sonntag William, E; Hereñú , C. B; Goya , R. G.
    . New York . New Encyclopedia of Neuroscience

  • Neuroendocrine Aging: Pituitary-metabolism
    Sonntag W. E; Hereñú, C. B.
    . New Encyclopedia of Neuroscience; p. 1-18


  • Premio al mejor trabajo en investigación básica en el 2º Congreso Internacional de la Facultad de Cs Médicas de la UNLP.
    Trabajo: Pardo, J; Abba, M; Lacunza, E; Schwerdt, J; Cónsole, G; Outeiro, T; Morel, G; Goya, R.  “Expresión génica diferencial de hipocampo en un modelo de envejecimiento cerebral tratado con terapia génica de largo plazo”. Presentación oral. Noviembre 2015.
  • Distinción otorgada al trabajo científico: “Transferencia génica asistida por campos magnéticos: estudios en células gliales”. Pardo, J; Sosa, Y. E; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G.
    ActaBioqClinLatinoam. 47 (2): 399-406 (2013)“  por parte de la Asociación de Prensa Científica de la República Argentina, para su publicación en un número especial, dedicado a la difusión de los diez trabajos científicos argentinos más destacados del año 2014, de edición binacional portugués-español del Acta Bioquímica Clínica Latinoamericana.
  • “Profesor Dr. Samuel M. Mc Cann 2007”
    Otorgado por la Sociedad Argentina de Fisiología en el marco de la Reunión 2007, realizada conjuntamente con las Sociedades Argentinas de Investigación clínica e Inmunología. Mar del Plata, 24 de Noviembre de 2007.
    Otorgado según el dictamen del jurado, al mejor trabajo sobre Neuroinmunoendocri- nología, titulado: Terapia génica neonatal para el péptido tímico timulina como estrategia preventiva de las alteraciones ováricas en el ratón congenitamenteatímico.
    Reggiani, P. C; Barbeito, C. G; Flamini, M. A; Cónsole , G.M; Rodríguez, S. S, Dardenne, M; Goya, R. G. 

  • “Profesor Doctor Manuel Litter”
    Otorgado por la Asociación Médica Argentina y la Sociedad Argentina de Farmacología y Terapéutica. Buenos Aires, 5 de Noviembre de 2007.
    Al mejor trabajo científico titulado: Restauración de de la función reproductiva en ratones inmunodeficientes por medio de terapia génica  con el gen del péptido timulina.
    Reggiani, P. C; Martínez, E.V; Camihort, G. A; Luna, G. C; Brown, O. A; Goya, R. G; Cónsole, G. M. 

  • “2000 Eukanuba Prize”,
    Al mejor trabajo argentino sobre medicina veterinaria, presentado en "The North American Veterinary Conference". January 13  al 17, 2001, Orlando, USA. 
    Título: Growth hormone reference range and stimulation tests in intact dogs. 
    Corrada, Y. A; Goya, R. G; Gobello, M. C.

  • “Premio Sandoz” 
    Al mejor poster presentado en el 186th Meeting of the Society for Endocrinology, Londres, 22 - 23 Noviembre de 1995. Conjuntamente recibido con Castro, M. G; Lowenstein, P. R; Sosa, Y. E.

  • “Premio bienal FABA 1993”
    Otorgado por la Federación Bioquímica de la Provincia de Buenos Aires.
    Trabajo: "Hormonas tímicas como mediadoras de la integración inmuno-gonadotropa".  Brown, O. A; Sosa, Y, E; Goya, R. G.

  • Invitado por la Fundación SANDOZ para Investigaciones Gerontológicas, para participar, como representante único de la región latinoamericana, en el Simposio Internacional "Mechanisms of Homeostasis in Aging", llevado a cabo en Basilea, Suiza, en marzo de  1992

  • 2º Premio Latinoamericano de Gerontología.
    Otorgado por la Federación Latinoamericana de Gerontología y Geriatría a los 3 mejores trabajos científicos presentados durante el 6º Congreso Latinoamericano de Gerontologia y Geriatría celebrado en Buenos Aires- 2 al 7 de octubre de 1988. 
    Título: "Cambios en los perfiles secretorios de somatotrofina y tirotrofina durante el envejecimiento en la rata".

  • Medalla y diploma otorgados por el Colegio de Bioquímicos de la Provincia de Buenos Aires al mejor egresado de la promoción 1982 en la Facultad de Ciencias Exactas de la Universidad Nacional de La Plata.

INIBIOLP - Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner"
Consejo Nacional de Investigaciones Científicas y Técnicas - Facultad de Ciencias Médicas - U.N.L.P.
Avenida 60 y 120 - C.P. 1900 La Plata - Prov. de Buenos Aires - Argentina. Tel. 54-221-4824894 - Fax. 54-221-4258988 - E-mail :