Mechanisms of interaction between monoterpenes, essential oils 
and statins on lipid metabolism and cellular proliferation

Team of work

García de Bravo, Margarita María
Principal Investigator
Crespo, Rosana
Polo, Mónica Patricia
Rodenak Kladniew, Boris Emilio
Research Fellow
Castro, María Agustina
Research Fellow
Peterson, Graciela
Support staff
Farquette, Mónica Cristina
Support staff

Collaborators from other institutions


Cicció, Alberti JF. 
Center for Natural Products Research (CIPRONA). University of Costa Rica. San José. Costa Rica

Line overview

Study of mechanism of action of isoprenoids and their interaction with statins on lipid metabolism and cell proliferation. Evaluation of hypolipemiant, antiaterogenic, and antitumoral properties of essential oils of citrus and aromatic plants.




  • Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound.
    Crespo, R; Wei, K; Rodenak-Kladniew, B; Mercola, M; Ruiz-Lozano, P; Hurtado, C.
    2017. Life Sciences, 172, 8-12

  • Inhibition of Mevalonate Pathway and Synthesis of the Storage Lipids in Human Liver-Derived and Non-liver Cell Lines by Lippia alba Essential Oils.
    Montero-Villegas, S; Polo, M; Galle, M; Rodenak-Kladniew, B; Castro, M; Ves-Losada, A; de Bravo, M. G.
    Lipids, 52(1), 37-49

  • Control of liver glucokinase activity: A potential new target for incretin hormones?
    Francini, F; Massa, M. L; Polo, M. P; Villagarcía, H; Castro, M. C; Gagliardino, J. J.
    Peptides. , Amsterdam: ELSEVIER SCIENCE INC, vol. 74, p. 57-63. ISSN 0196-9781

  • Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum -cholesterol and triglyceride levels.
    Galle, M; Rodenak Kladniew, B; Castro, M. A; Montero Villegas, S; Lacunza, E; Polo, M; García De Bravo, M; Crespo, R.
    Phytomedicine. , Amsterdam: ELSEVIER GMBH, vol. 22, p. 696-704. ISSN 0944-7113

  • Suppression by geraniol of the growth of A549 human-lung adenocarcinoma cells and inhibition of the mevalonate pathway in culture and in vivo: potential use in cancer chemotherapy. 
    Galle, M; Crespo, R; Rodenak Kladniew, B; Montero Villegas, S; Polo, M; De Bravo, M. G. 
    2014. Nutrition and Cancer. : LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS,. vol. 66, p. 888-895. ISSN 0163-5581

  • Synergistic antiproliferative and anticholesterogenic effects of linalool, 1,8-cineole and simvastatin on human cell lines.
    Rodenak Kladniew, B; Polo, M; Montero Villegas, S; Galle, M; Crespo, R; De Bravo, M. G. 
    2014. Chemico-Biological Interactions. , Amsterdam: ELSEVIER IRELAND LTD,. vol. 214, p. 57-68. ISSN 0009-2797
  • Actividad antiproliferativa y anticolesterogénica de estatinas y monoterpenos. 
    Polo, M; Crespo, R; Galle, M; Rodenak Kladniew, B; Montero Villegas, S; Garcia de Bravo, M. 
    2013. Federación Bioquímica Provincia Buenos Aires. Acta Bioquímica Clínica Latinoamericana. vol. 47, n° 2, p. 343-351. ISSN 0325-2957
  • In vitro comparative analysis of antiproliferative activity of essential oil from mandarin peel and its principal component limonene
    Manassero, C; Girotti, J. R; Mijailovsky, S; García de Bravo, M; Polo, M. 
    2013. Natural Product Research. Londres: Taylor & Francis LTD, 2013 - . vol. 27, p. 1475-1478. ISSN 1478-6419
  • Nuclear lipid droplets: a novel nuclear domain. 
    Layerenza, J. P; González, P; García de Bravo, M; Polo, M; Sisti, M. S; Ves-Losada, A. 
    2013. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. Amsterdam: ELSEVIER SCIENCE BV, 2013 - . vol. 1831, p. 327-340. ISSN 1388-1981
  • Origen y distribución espacial de linajes maternos nativos en el noroeste y centro oeste argentinos/ Origin and spatial distribution of native maternal lineages in Northwest and Center West of Argentina. 
    Motti, J. M. B; Muzzio, M; Ramallo, V; Rodenak, B; Alfaro, E. L; Dipierri, J. E; Bravi, C. M; Bailliet, G.
    2013. Revista argentina de Antropología Biológica. Universidad Nacional de La Plata. vol. 15, n° 1, p. 3-14. ISSN 1853-6387
  • Transcriptional and posttranscriptional inhibition of HMGCR and PC biosynthesis by geraniol in two HEP-G2 cellproliferation-linked pathways. 
    Crespo, R; Montero Villegas, S; Abba, M. C; García. De Bravo, M; Polo, M. P.
    2013. Biochemistry and Cell Biology. Otawa: Natl Research Council Canada-N R C Research Press. vol. 91, p. 131-139. ISSN 0829-8211
  • Thymulin-based gene therapy and pituitary function in animal models of aging.
    Reggiani, P. C; Poch, B; Cónsole, G. M; Rimoldi, O. J; Schwerdt, J. I; Tüngler, V; García-Bravo, M. M; Dardenne, M; Goya, R. G.
    2011. Neuroimmunomodulation 18, 350-356. Editorial: Karger Medical and Scientific Publishers.
  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.
    Crespo, R; Villaverde, M. L; Girotti, J. R; Güerci, A; Juarez, M. P; García de Bravo, M. 
    2011. J Ethnopharmacol 136, 204–209
  • Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. 
    Polo, M. P; Crespo, R; García de Bravo, M. 
    2011. Cell Biochem Funct 29, 452–458
  • In vitro antitumor activity of N-glycosyl sulfonamides.
    Crespo,R; García de Bravo, M; Colinas, P. A; Bravo, R. D.
    2010. Bioorg Med Chem Lett. 20, 6469-6471

  • Effect of geraniol on fatty acid and mevalonate metabolism in the human hepatoma cell line Hep G2. 
    Polo, M. P; García de Bravo, M. 
    2006. Biochem Cell Biol 84,102-111. Con referato

INIBIOLP - Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner"
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