Modulation of inflammatory response and glial cells reactivity
in neurodegeneration models.


Team of work
  Bellini, María José
  Principal Investigator
  mariajosebellini@yahoo.com
  Falomir Lockhart, Eugenia
  Research Fellow
  eugefalomir@gmail.com
  Dolcetti, Franco Juan Cruz
  Research Fellow
  franco.dolcetti@gmail.com
  Anesetti, Soledad
  Dissertation Student
  Scelsio, Natalia
  Support staff
  scelsionatalia@gmail.com
  Bigres, Araceli
  Support staff
  aracelibigres@gmail.com
 Lofeudo, Juan Manuel
 Support staff
  juanmalofeudo@hotmail.com
   


Collaborators from other institutions

International

García-Segura, Luis Miguel
Instituto Cajal, Madrid, España.

Diz-Chaves, Yolanda
Instituto Cajal, Madrid, España.


National

Correa, Fernando
Centro de Estudios Farmacológicos y Botánicos (CEFyBO), Facultad de Ciencias Médicas, UBA.

Hereñú, Claudia B.
IFEC- Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba.

Labombarda, Florencia
Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas - (IBYME -CONICET).

Perelló, Mario
Instituto Multidisciplinario de Biología Celular, IMBICE, La Plata.

Pietranera, Luciana
Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas - (IBYME -CONICET).
 

Ramos, Alberto Javier
Instituto de Biología Celular y Neurociencia "PROFESOR EDUARDO DE ROBERTIS" (IBCN), Facultad de Medicina, UBA.



Line overview

Main interests:
Our main interest is focused on elucidate the mechanisms leading to neurodegeneration during aging, basically those related to the inflammatory response.
The essential objective of our work is to develop therapeutic strategies that recover age-affected neuronal populations.
The possibility of employing neurotrophic factors that prevent neurodegeneration, increase neuron recovery and regulate inflammatory response is clinically relevant.

Inflammation
Chronic inflammation plays a key role in most common neurodegenerative diseases.
A possible therapeutic target for the treatment of the disease can be blocking the source of that inflammation.
Microglia and astrocytes are the main effector cells that contribute to brain inflammation.

Objectives:

  • To investigate the possible restoring, neuroprotective, and/or anti-inflammatory effects of IGF-I in aging rodents and experimental models of neurodegenerative diseases.
  • To determine if aging and sexual differences can affect their neuroprotective action.
  • To elucidate the cellular and molecular mechanisms of the anti-inflammatory activity of IGF-I in the brain.
  • To study the role of glial cells as mediators of IGF-I effects.
  • To characterize the changes in the lipid composition associated to age and sex.

Lines of work

1-Cell reprogramming and gene therapy for the treatment of motor dopaminergic neurodegeneration.

Principal Investigator: Eugenia Falomir-Lockhart

The ultimate objective of the present project is to study comprehensively the motor-nervous system applying strategies of gene therapy and regenerative medicine in the dopaminergic system (nigro-striatal) in order to improve the age-related deficiencies in the motor pathways of the encephalic dopaminergic system.

2-Hypothalamus as aging regulating center - Anti-inflammatory gene therapy.

Principal Investigator: Franco Dolcetti

The central hypothesis of the present plan is that the transfer of neuroprotective genes constitutes an effective strategy to diminish the inflammatory response in the aging, constituting a possible treatment of diverse age-related neurodegenerative processes. In particular we consider that intrahypothalamic gene therapy for insulin-like growth factor type I (IGF-I) would module the immune response with the subsequent delay in the onset of aging-associated damages and/or their improvement once they have occurred.

Aging is the result of multiple physiological changes, and the hypothalamus can be an underlying mediator representing a target of controlling strategies to counteract aging and aging-related diseases.

 

Publications

 

  • Exploring the effects of IGF-1 gene therapy to modulate neuroinflammation.
    Falomir-Lockhart, E; Dolcetti, F. J. C; Anesetti-Nelli , S. J; Hereñu, C. B; Bellini, M. J.
    2017. Glia: Wiley-Liss, Div John Wiley & Sons Inc. vol. 65, n° S1, p. 90-91. ISSN 0894-1491

  • Deterioro cognitivo asociado a la patología parkinsoniana: El rol del hipocampo.
    Herrera, M. L; Falomir Lockhart, E; Dolcetti, F. J. C; Bellini, M. J; Hereñu, C. B.
    2016. Ciencia insitu: Federación Argentina Científica de Estudiantes de la Salud, vol. 1, n° 2, p. 23-27. ISSN 2469-2433

  • Magnetofection enhances adenoviral vector-based gene delivery in skeletal muscle cells.
    Pereyra, A. S; Mykhaylyk, O; Falomir Lockhart, E; Taylor, J. R; Delbono, O; Goya, R. G; Plank, C; Hereñu, C. B.
    2016.
    Journal of Nanomedicine & Nanotechnology 04/2016; 7(364)

  • Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1 and enhances skeletal muscle force in aging sedentary mice.
    Zhang, T; Pereyra, A. S; Wang, Z. M; Birbrair, A; Reisz, J. A; Files, C. D; Purcell, L; Feng, X; Messi, M. L; Feng, H; Chalovich, J; Jin, J-P; Furdui, C; Delbono, O.
    2016. Aging Cell. 2016 Feb 19. doi: 10.1111/acel.12453


  • Troponin T3 regulates nuclear localization of the calcium channel CavB1a subunit in skeletal muscle.
    Zhang, T; Taylor, J; Jiang, Y; Pereyra, A. S; Messi, M; Wang, Z. M; Hereñú, C; Delbono, O.
    2015. Experimental Cell Research. 2015 May 15; 336 (2): 276-286

  • Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.
    D. Clark Files; Liu, C; Pereyra, A. S; Zhong-Min Wang; Aggarwal, N; D´Alessio, F; Delbono, O.
    2015. Science Translational Medicine. , Washington: American Association for the Advancement of Science, vol. 7, n° 278, p. 278-310. ISSN 1946-6234

  • Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats.
    Morel, G; Andersen, T; Pardo, J; Zucolilli, G. O; Cambiaggi, V. L; Hereñú, C; Goya, R. G.
    2015.
    Neuroscience. , Amsterdam: PERGAMON-ELSEVIER SCIENCE LTD, p. 189-199. ISSN 0306-4522

  • Regional research priorities in brain and nervous system disorders
    Ravindranath, V; Dang, H. M; Goya, R. G; Mansour, H; Nimgaonkar, V. L; Russell, V. A; Xin, Y.
    2015. Nature, 527: S198–S206

  • Estrogen actions on glial reactivity and inflammation-mediated memory impairment: Sex differences and interaction with other neurotrophic factors.
    Bellini, M. J.
    2015. González-Burgos (Ed.); Nova Science Publishers, July 01, 2015, Pages 155-174

  • Neuroprotective gene therapy in the aging brain.
    Pardo, J; Morel, G. R; Pereyra, A. S; López-León, M; Brown-O. A, Bellini, M. J; Goya, R. G.
    2014. Estrogens and Cognition. Psycho-biological and Clinical Aspects: González-Burgos (Ed.) ISBN: 978-81-308-0550-4; pp.97-117

  • Therapeutic potential of the thymic peptide thymulin
    Reggiani, P. C; Schwerdt, J. I; Cónsole, G. M; Roggero, E; Dardenne, M; Goya, R. G.
    2014. Current Pharmaceutical Design, 20: 4690-4696


  • Physiology and therapeutic potential of the thymic peptide thymulin.
    Reggiani, P. C; Schwerdt, J. I; Console, G. M; Roggero, E. A; Dardenne, M; Goya, R. G. 
    2014. Current Pharmaceutical Design. , Oak Park: BENTHAM SCIENCE PUBL LTD,. vol. 20, n° 29, p. 4690-4696. ISSN 1381-6128
  • Regenerative Medicine for the Aging Brain.
    Lopez Leon, M; Reggiani, P; Hereñú, C; Goya, R.
    2014. Herbert Publication,. vol. 1, n° 1, p. 1-9. ISSN 2050-1218.
    Enliven J Stem Cell Res Regen Med.
  • The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells.
    Taylor, J; Pereyra, A. S; Zhang, T; Messi, M. L; Zhong-Min Wang; Hereñú, C; Pei-Fen Kuan; Delbono, O. 
    2014. Journal of Cell Biology. , New York: ROCKEFELLER UNIV PRESS,.vol. 205, n° 6, p. 829-846. ISSN 0021-9525
  • DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma.
    Da Silva, A.L; Martini, S. V; Abreu, S.C; Samary, C. D; Diaz, B. L; Fernezlian S de Sá, V. K; Capelozzi, V. L; Boylan, N. J; Goya, R. G; Suk, J. S; Rocco, P. R; Hanes, J; Morales, M. M.
    2014. Journal of Controlled Release. Amsterdam: ELSEVIER SCIENCE BV. vol. 180, p. 125-133. ISSN 0168-3659
  • Gene therapy and cell reprogramming for the aging brain: achievements and promise.
    Pardo, J; Morel, G. R; Astiz, M; Schwerdt, M. I; López León, M; Rodríguez, S. S;Hereñú, C. B; Goya, R. G. 
    2014. Curr Gene Ther; 14:24-34
  • Transferencia génica asistida por campos magnéticos: estudios en células gliales.
    Pardo, J; Sosa, Y; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G. 
    2013. Acta Bioquímica Clínica Latinoamericana. La Plata: Federacion Bioquímica Provincia Buenos Aires, vol. 47, n° 2, p. 399-406. ISSN 0325-2957
  • The thymulin-lactotropic axis in rodents: thymectomy, immunoneutralization and gene transfer studies.
    Martines, E. V; Reggiani, P. C; Camihort, G; Luna, G; Zappa, M. F; Brown, O. A; Goya, R. G; Cónsole, G. M. 
    2013Neuroimmunomodulation. Basel: Karger. vol. 20, p. 256-263. ISSN 1021-7401
  • Hypothalamic insulin-like growth factor-I gene therapy prolongs estral cyclicity and protects ovarian structure in middle-aged female rats.
    Rodriguez, S. S; Schwerdt, J. I; Barbeito, C. G; Flamini, A. M; Han, Y; Bohn, M. C; Goya, R. G.
    2013. Endocrinology.Bethesda: Endocrine Soc. vol. 154, n° 6, p. 2166-2173. ISSN 0013-7227
  • Magnetic field-assisted gene transfer: Studies in glial cells (in Spanish).
    Pardo, J; Sosa, Y. E; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G. 
    2013. Acta Bioquímica Latinoamericana; 47: 399-406
  • Role of copper and cholesterol association in the neurodegenerative process.
    Arnal, N; Morel, G. R; Tacconi de Alaniz, M. J; Dominici, L; Marra, C. A.  
    2013. Int J Alzheimers Dis; 2013:414817. doi: 10.1155/2013/414817. Epub 2013 Oct 29
  • Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β. 
    Grassi, D; Bellini, M. J; Acaz-Fonseca, E; Panzica, G; Garcia-Segura, L. M. 
    2013. Endocrinology. 154: 2092-100
  • Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice. 
    Diz-Chaves, Y; Astiz, M; Bellini, M. J; Garcia-Segura, L. M. 
    2013Brain Behavior and Immunity. Amsterdam: Academic Press Inc Elsevier Science. vol. 28, p. 196-206. ISSN 0889-1591
  • Magnetic field-assisted gene delivery: achievements and therapeutic potential.
    Schwerdt, J. I; Goya, G. F; Calatayud, P; Hereñu, C; Reggiani, P. C; Goya, R. G. 
    2012. Current gene therapy. , Oak Park: Bentham Science Public  Ltd, vol. 12,n° 1, p. 116-126


  • Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuates reproductive derangements in nude female mice.
    Reggiani, P. C; Barbeito, C. G; Zuccolilli, G. O; Cónsole, G. M; Flamini, A. M; Dardenne, M; Goya, R. G. 
    2012. Endocrinology. : Endocrine Soc, vol. 153, n° 8, p. 3922-3928


  • Role of thymulin on the somatotropic axis in vivo. 
    Reggiani, P.C; Martinez,  E; Camihort, G.A; Poch, B; Goya, R. G; Console, G. M. 
    2012. Life Sciences, Amsterdam: Pergamon - ElSevier Science Ltd, vol. 91, p. 166-171

  • Influence on Effectiveness of Early Treatment with Anti-TNF Therapy in Rheumatoid Arthritis. 
    Escudero-Vilaplana, V; Ramírez-Herraiz, E; Trovato-López, N; Alañón-Plaza, E; Bellini, M; Herranzalonso, A; Bellón-Cano, J.M; Morell-Baladrón, A; Sanjurjo-Sáez, M. 
    2012. Journal of pharmacy and pharmaceutical sciences. : Canadian Soc Pharmaceutical Sciences, vol. 15, n° 3, p. 355-360

  • Selective oestrogen receptor modulators decrease the inflammatory response of glial cells. 
    Arevalo, M.A; Diz-Chaves, Y; Santos-Galindo, M; Bellini, M.J; Garcia-Segura, L.M. 
    2012. Journal of neuroendocrinology. Oxford: Wiley-Blackwell Publishing, Inc, vol. 24, p. 183-190
  • Increased romatase expression in the hippocampus of spontaneously hypertensive rats: effects of estradiol administration. 
    Pietranera, L; Bellini, M. J;  Arévalo, M. A; Goya, R; Brocca, M. E; García Segura, L. M; De Nicola, A. F.
    2011. Neuroscience, 174p. 151-159
  • Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells.
    Reggiani, P. C; Poch, B; Cónsole, G. M; Rimoldi, O. J; Schwerdt, J. I; Tüngler, V; García-Bravo, M. M; Dardenne, M; Goya, R. G.
    2011.  J Ethnopharmacol 136, 204–209. Editorial: Elsevier.
  • Increased number of neurons in the cervical spinal cord of aged female rats.
    Portiansky, E. L; Nishida, F; Barbeito, C. G; Gimeno, E. J; Goya, R. G.
    2011. PloS One, 6: e22537
  • Insulin-like growth factor I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide.
    Bellini, M. J; Hereñú, C. B; Goya, R. G; García Segura, L. M.
    2011. Neuroinflammation,  8: 21
  • Restorative effect of intracerebroventricular Insulin-like Growth Factor-I gene therapy on motor performance in aging rats.
    Nishida, F; Morel, G. R; Hereñú, C. B; Schwerdt, J. I; Goya, R. G; Portiansky, E.L
    2011. Neuroscience, 177: 195 - 206
  • Thymulin-based gene therapy and pituitary function in animal models of aging.
    Reggiani, P. C; Poch, B; Cónsole, M. G; Rimoldi, O. J; Schwerdt, J. I; Tüngler, V; García de Bravo, M. M; Dardenne, M; Goya, R. G.
    2011. Neuroimmuno-modulation,  18: 350-356
  • Morphological effects on the corticotrope population by thymulin gene therapy in nude mice.
    Martinez, E. V; Reggiani, P. C; Schwerdt, J. I; Goya, R. G; Cónsole, G. M.             
    2011. Histology and Histopathology; 26: 471-479
  • Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.
    Martinez, E. V; Reggiani, P. C; Schwerdt, J. I; Goya, R. G; Cónsole, G. M.
    2011. Cells, Tissues, Organs, 194: 67-75
  • Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior; adult mice: a potential model of geriatric depression.
    Mitschelen, M; Yan, H; Farley, J. A; Warrington, J. P; Han, S; Hereñú, C. B; Csiszar, A; Ungvari, Z; Bailey-Downs, L. C; Bass, C. E; Sonntag, W. E. 
    2011. Neuroscience; 185: 50 - 60
  • Morphological changes induced by insulin-like growth factor-I gene therapy in pituitary cell populations in experimental prolactinomas. 
    Camihort, G. A; Hereñú, C. B; Luna, G. C; Rodríguez, S. S; Bracamonte, M. I; Goya, R. G; Cónsole, G. M.
    2010. Cells tissues organs. Karger. vol. 191, p. 316-325


  • Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats
    Morel, G. R; Sosa, Y. E; Bellini, M. J; Carri, N. G; Rodriguez, S, S; Bohn, M. C; Goya, R.
    2010
    . Neuroscience; vol. 167 p. 946 - 953
  • Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord. 
    Rodríguez de Amorim, M. A; García-Segura,  L. M; Goya, R, G; Portiansky, E. L.2010Experimental gerontology. Pergamon-Elsevier Science Ltd. vol. 45, p. 457-463
  • Carbohydrates and glycoforms of the major egg perivitellins from Pomacea apple snails (Architaenioglossa: Ampullariidae).
    Morel, G; Sosa, Y. E; Bellini, M. J; Carri, N. G; Rodriguez, S; Bohn, M. C; Goya, R. G. 
    2010. Neuroscience. Pergamon-Elsevier Science Ltd. vol. 167, p. 946-953
  • The ependymal route for insulin-like growth factor-1 gene therapy in the brain. 
    Hereñu C. B; Sonntag W.E; Morel G. R; Portiansky E. L; Goya R. G. 
    2009. Neuroscience. Elsevier, vol. 163, p. 442-447
  • Morphological Restoration of Gonadotrope Population by Thymulin Gene Therapy in Nude Mice. 
    Reggiani P; Martínez E; Ferese C; Goya R; Cónsole G. 
    202009. Histology and Histopathology. Murcia, Spain: Gutenberg, vol. 24,nº6, p.729-735
  • The thymus-neuroendocrine axis: physiology, molecular biology and therapeutic potential of the thymic peptide thymulin.
    Reggiani P.C; Morel G. R; Cónsole G. M; Barbeito C. G; Rodriguez S; Brown O. A; Bellini M. J; Pléau J. M; Dardenne M; Goya R. G. 
    2009. Annals of the New York Academy of Sciences. New York: New York Academy of Sciences. Blackwell Publishing, vol. 1153, p. 98-106
  • Effect of insulin-like growth factor- I gene therapy on the somatotropic axis in experimental prolactinomas. 
    Console G.M; Hereñú C. B; Camihort G. A; Luna G. C; Ferese C; Goya R.G. 
    2009. Cells Tissues Organs. Basel: Karger AG, vol. 190, p. 20-26
  • Estrogen inhibits tuberoinfundibular dopaminergic neurons but does not cause irreversible damage.
    Morel, G. R; Caron, R. W; Console, G. M; Soaje, M; Sosa, Y. E; Rodríguez, S. S; Jahn, G. A; Goya, R. G. 
    2009. Brain Research Bulletin. Amsterdam: Elsevier, vol. 80, n° 6, p. 347-352
  • Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas. 
    Console, G. M; Hereñu, C. B; Camihort, G. A; Luna, G. C; Bracamonte, M. I; Morel, G. R; Goya, R. G. 
    2008. Molecular cancer. Londres: Blackwell Scientific Publications, p. 7-13
  • Dopaminergic mesencephalic systems and motor performance in very old rats. 
    Sánchez, H. L; Silva, L. B; Portiansky, E. L; Hereñu, C. B; Goya, R. G. 
    2008. Neuroscience. USA: Elsevier, vol. 154, n° 4, p. 1598-1606
  • Preventive action of neonatal gene therapy with the thymic hormone thymulin on the ovarian atrophy of adult nude mice.
    Reggiani, P.C; Flamini, M. A; Rodriguez, S. S; Goya, R. G; Barbeito, C. G. 
    2008. Biocell. Mendoza: IHEM-CONICET, vol. 32, p. 137-137
  • Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models. 
    Morel, G. R; Reggiani, P. C; Cónsole, G. M; Rimoldi, O. J; Vesenbeckh, S. M; García De Bravo, M; Rodríguez, S. S; Brown, O. A; Goya, R. G. 
    2008.Curr gene ther. Bentham Science Publishers, vol. 8,n° 1,p.49-53.ISSN 1566-5232
  • Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models.
    Morel G. R; Reggiani P. C; Console, G. M; Rimoldi, O. J; Vesenbeckh, S. M; Garcia De Bravo M. M; Rodriguez, S. S; Brown, O. A; Goya, R. G. 
    2007. Curr gene ther... vol. 8, p. 49-53
  • PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes. 
    Cristina, C; Diaz Torga, G; Goya, R. G; Kakar, S. S; Perez Millan, M. I; Giannella Neto, D; Bronstein, M. D; Becu Villalobos, D. 
    2007. Molecular cancer. Inglaterra: BMC. vol. 6, p. 4-9
  • Fatty acid profiles in hepatic membranes of rats with different levels of circulating estrogen and prolactin. 
    Bellini, M. J; Carino, M; Tacconi de Gomez Dumm, I. N; Goya, R. G. 
    2007. Comparative biochemistry and physiology molecular and integrative physiology. USA: Elsevier. vol. 146, p. 470-474
  • Restorative effect of Insulin-like Growth Factor-I Gene Therapy in the Hypothalamus ofsenile rats with Dopaminergic dysfunction.
    Hereñu, C. B; Cristina, C; Rimoldi, O. J; Becu-Villalobos, S; Cambiaggi, V; Portiansky, E. L; Goya, R. G. 
    2007. Gene therapy. Nature Publishing Group. vol. 14, p. 237-245. ISSN 0969-7128
  • Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. 
    Goya, R. G; Reggiani, P. C; Vesenbeckh, S. M; Pleau, J. M; Sosa, Y. E; Console, G. M; Schade, R; Henklein, P; Dardenne, M. 
    2007. American journal of physiology-endocrinology and metabolism. American Physiological Society. vol. 293, p. 182-187

Book - Book chapters

  • Logros y promesas de la medicina regenerativa en el tratamiento de enfermedades neurodegenerativas.
    López-León, M; Lehmann, M; Goya, R. G.
    2016. Universidad de Murcia (Master); 6º Ed.; Viguera Editores SLU; Barcelona; 2016. Capítulo en el libro “Desordenes del Movimientro”.


  • Medicina regenerativa para el tratamiento de enfermedades nuerodegenerativas.
    López-León, M: Goya, R. G.
    2015. Universidad de Murcia (Master); 5º Ed.; Viguera Editores SLU; Barcelona. Capítulo en el libro “Desordenes del Movimientro”
  • Gene Delivery Systems. 
    Pereyra, A. S; Hereñu, C. B.; Romanovsky, V; Zgela, V; Bakic, S.
    2013. Editorial InTech, p. 165-192. ISBN 978-953-51-1207-5
  • Neuroendocrine system and aging: growth hormone, thyroid stimulating hormone, prolactin and insulin.
    Sonntag William, E; Hereñú , C. B; Goya , R. G.
    2008
    . New York . New Encyclopedia of Neuroscience


  • Neuroendocrine Aging: Pituitary-metabolism
    Sonntag W. E; Hereñú, C. B.
    2006
    . New Encyclopedia of Neuroscience; p. 1-18


Awards

  • Premio al mejor trabajo en investigación básica en el 2º Congreso Internacional de la Facultad de Cs Médicas de la UNLP.
    Trabajo: Pardo, J; Abba, M; Lacunza, E; Schwerdt, J; Cónsole, G; Outeiro, T; Morel, G; Goya, R.  “Expresión génica diferencial de hipocampo en un modelo de envejecimiento cerebral tratado con terapia génica de largo plazo”. Presentación oral. Noviembre 2015.
  • Distinción otorgada al trabajo científico: “Transferencia génica asistida por campos magnéticos: estudios en células gliales”. Pardo, J; Sosa, Y. E; Reggiani, P. C; Arciniegas, M. L; Sánchez, F; Goya, R. G.
    ActaBioqClinLatinoam. 47 (2): 399-406 (2013)“  por parte de la Asociación de Prensa Científica de la República Argentina, para su publicación en un número especial, dedicado a la difusión de los diez trabajos científicos argentinos más destacados del año 2014, de edición binacional portugués-español del Acta Bioquímica Clínica Latinoamericana.
  • “Profesor Dr. Samuel M. Mc Cann 2007”
    Otorgado por la Sociedad Argentina de Fisiología en el marco de la Reunión 2007, realizada conjuntamente con las Sociedades Argentinas de Investigación clínica e Inmunología. Mar del Plata, 24 de Noviembre de 2007.
    Otorgado según el dictamen del jurado, al mejor trabajo sobre Neuroinmunoendocri- nología, titulado: Terapia génica neonatal para el péptido tímico timulina como estrategia preventiva de las alteraciones ováricas en el ratón congenitamenteatímico.
    Reggiani, P. C; Barbeito, C. G; Flamini, M. A; Cónsole , G.M; Rodríguez, S. S, Dardenne, M; Goya, R. G. 

  • “Profesor Doctor Manuel Litter”
    Otorgado por la Asociación Médica Argentina y la Sociedad Argentina de Farmacología y Terapéutica. Buenos Aires, 5 de Noviembre de 2007.
    Al mejor trabajo científico titulado: Restauración de de la función reproductiva en ratones inmunodeficientes por medio de terapia génica  con el gen del péptido timulina.
    Reggiani, P. C; Martínez, E.V; Camihort, G. A; Luna, G. C; Brown, O. A; Goya, R. G; Cónsole, G. M. 

  • “2000 Eukanuba Prize”,
    Al mejor trabajo argentino sobre medicina veterinaria, presentado en "The North American Veterinary Conference". January 13  al 17, 2001, Orlando, USA. 
    Título: Growth hormone reference range and stimulation tests in intact dogs. 
    Corrada, Y. A; Goya, R. G; Gobello, M. C.

  • “Premio Sandoz” 
    Al mejor poster presentado en el 186th Meeting of the Society for Endocrinology, Londres, 22 - 23 Noviembre de 1995. Conjuntamente recibido con Castro, M. G; Lowenstein, P. R; Sosa, Y. E.

  • “Premio bienal FABA 1993”
    Otorgado por la Federación Bioquímica de la Provincia de Buenos Aires.
    Trabajo: "Hormonas tímicas como mediadoras de la integración inmuno-gonadotropa".  Brown, O. A; Sosa, Y, E; Goya, R. G.

  • Invitado por la Fundación SANDOZ para Investigaciones Gerontológicas, para participar, como representante único de la región latinoamericana, en el Simposio Internacional "Mechanisms of Homeostasis in Aging", llevado a cabo en Basilea, Suiza, en marzo de  1992

  • 2º Premio Latinoamericano de Gerontología.
    Otorgado por la Federación Latinoamericana de Gerontología y Geriatría a los 3 mejores trabajos científicos presentados durante el 6º Congreso Latinoamericano de Gerontologia y Geriatría celebrado en Buenos Aires- 2 al 7 de octubre de 1988. 
    Título: "Cambios en los perfiles secretorios de somatotrofina y tirotrofina durante el envejecimiento en la rata".

  • Medalla y diploma otorgados por el Colegio de Bioquímicos de la Provincia de Buenos Aires al mejor egresado de la promoción 1982 en la Facultad de Ciencias Exactas de la Universidad Nacional de La Plata.





INIBIOLP - Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner"
Consejo Nacional de Investigaciones Científicas y Técnicas - Facultad de Ciencias Médicas - U.N.L.P.
Avenida 60 y 120 - C.P. 1900 La Plata - Prov. de Buenos Aires - Argentina. Tel. 54-221-4824894 - Fax. 54-221-4258988 - E-mail :